New aminocyclitols as modulators of glucosylceramide metabolism.
نویسندگان
چکیده
A series of 13 aminocyclitol derivatives belonging to two different families is described. Their configuration is governed by the regio- and stereocontrolled epoxide opening of a suitably protected conduritol-B epoxide. Studies on several glycosyl processing enzymes indicate that some of them are good inhibitors of glucosylceramide hydrolase. A rationale to account for preliminary structure-activity relationships is provided.
منابع مشابه
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ورودعنوان ژورنال:
- Organic & biomolecular chemistry
دوره 3 7 شماره
صفحات -
تاریخ انتشار 2005